Skin boosters · treatment guide

Rejuran Healer 리쥬란 힐러

The salmon-DNA skin booster: gentle glow, short downtime, and hard to get at home.

Seoul this week₩209,000$151 · 71 clinicsReviewed 2026-09-23 · sources
Our takeThe easiest Seoul treatment to fit into a four-day trip, and one you often can't get back home.
Best for
  • Short trips (3+ days)
  • First-timers
  • Dull, dehydrated or tired-looking skin
  • Fine lines and early texture
Skip if
  • You want lifting or a sharper jawline
  • You hate needles and won't take numbing
  • You're pregnant or breastfeeding
Downtime8/10
Bumps are almost unnoticeable after about 24 hours and makeup is fine from then; clinics put full downtime at 2–3 days at most (Smart Skin Clinic).
Comfort4/10
Even after 30 minutes of numbing cream, women in a 2026 Rejuran trial rated standard intradermal injections about 6/10 for pain (5/10 for deeper injections); HB Plus adds lidocaine.
Evidence6/10
One small randomised split-face trial (27 people) found PN matched an HA booster, and a 2025 review of 9 studies (219 patients) rated the rest low-to-moderate quality; several recent trials were funded by makers.
Trip-friendly6/10
One 30–40 minute visit with no flying limits, but the full effect needs 3–4 sessions about 3 weeks apart and builds over weeks.
Seoul value8/10
Not sold in the US; Seoul's ₩209,000 for 2cc is roughly 20–25% of a Singapore session (S$600–1,000) or an Australian Healer syringe (A$900–1,200).
Glow7/10
Trials show measurable gains in fine lines, roughness and elasticity, with most people rated improved by week 12, but the change is subtle and similar to an HA booster.

Higher is better for a traveller. Tap a score to see why.

Pros and cons in full
What we like
  • Short visible downtime: bumps mostly gone in 24 hours
  • Not FDA-approved in the US, so Seoul may be the easiest place to get it
  • Made in Korea, so clinics use it constantly and prices are competitive
  • Natural-looking change: better skin, not a different face
  • Easy to combine with lifting in one visit
Watch out for
  • One of the more painful skin boosters. Ask for HB Plus or a nerve block
  • One session is only part of the full 3–4 session course
  • Results build gradually; don't expect an instant transformation
  • Bruising is possible and can take 1–2 weeks to fade
  • The research is encouraging but still small-scale
Live price · October 2026

How much is Rejuran in Seoul this week?

verified 2026-10-12

In Seoul, Rejuran costs a median of ₩209,000 (about $151) across 71 clinic listings this week, ranging from ₩135,000 to ₩539,000.

Korean median · ₩209,000
FairTourist priceOverchargedKorean prices seen: ₩135,000 – ₩539,000 · 71 clinics
Seoul (Korean price)₩209,000 ≈ $151
United StatesNot FDA-approved · Only available off-label at a few clinics
SingaporeS$600 – S$1,000 · per session
AustraliaA$900 – A$1,200 · per syringe of Rejuran Healer; A$1,000–2,000 for a full-face session

Seoul prices are event listings on Gangnam Unni's Korean app, VAT included. Many are first-visit or trial deals, clinics can show foreigners different prices, and the tourist VAT refund ended in 2025. How Korean clinic prices work →

Korean listings we checked

6 of the 12 listings shown are promotions (first visit, trial price or once per person). A repeat or regular booking usually costs more. How Korean clinic prices work →

ClinicAs listedSeenPrice
더끌림산부인과의원리쥬란 2cc · VAT 포함2026-10-12₩135,000
명동아이디의원리쥬란힐러 2CC · VAT 포함2026-10-12₩141,900
나인피부과-강남점1회 체험 리쥬란힐러2cc _더마샤인 팁포함 · VAT 포함Trial price2026-10-12₩148,500
Show all 12 listings
ClinicAs listedSeenPrice
유앤아이의원-잠실점첫방문) 리쥬란힐러 2cc 1회 체험가 · VAT 포함First visit onlyTrial price2026-10-05₩148,500
톤즈의원-건대점톤즈 리쥬란 힐러 2CC + LED + 진정머미 · VAT 포함2026-10-12₩150,000
유앤아이의원-영등포점첫방문) 리쥬란힐러 2cc 1회 체험가 · VAT 포함First visit onlyTrial price2026-10-05₩152,900
톡스앤필의원-홍대점(첫방문)리쥬란힐러 2CC 1회 · VAT 포함First visit only2026-10-12₩159,500
톤즈의원-강남역점리쥬란힐러 2cc · VAT 포함2026-10-12₩160,000
톤즈의원-명동점리쥬란힐러 2cc · VAT 포함2026-10-12₩160,000
루비의원리쥬란힐러_2cc · VAT 포함2026-10-12₩162,000
클래스원의원리쥬란힐러 2cc (첫방문 이벤트) · VAT 포함First visit only2026-10-12₩162,800
뽀송의원 (1회체험가) 리쥬란 힐러 2cc 1회 · VAT 포함Trial price2026-10-05₩163,900
Cost per month of result: ₩69,667
Cost per month of result
₩69,667 / month ≈ $50

3 sessions × ₩209,000, lasting about 9 months. After a first course of 3–4 sessions, clinics advise a top-up every 6–12 months; published studies only follow people for 3–6 months.

  1. Potenza RF Microneedling₩64,167
  2. Juvelook₩65,967
  3. Rejuran Healer₩69,667
  4. Thermage FLX₩110,000
  5. Sculptra₩110,000

Uses this week's Seoul median and the typical duration from studies. Other treatments use their midpoint duration and usual first course.

Downtime

Rejuran downtime, day by day

Bumps are almost unnoticeable after about 24 hours and makeup is fine from then; clinics put full downtime at 2–3 days at most (Smart Skin Clinic).

Day 0

Right after

Rows of small raised bumps, like mosquito bites, often with some redness.

AI-generated models, not real patients. Effects are illustrated to show typical healing; everyone heals differently. Compare the untreated baseline with a selected temporary recovery stage.

Trip planner

When to get Rejuran on your trip

Day 1 or 2 of your trip, so any bumps are gone before the sightseeing photos.

Any of these apply to you?
⏳

Before your flight home

At least 2 full days. Leave a week if you have an important event right after, in case of bruising.

↻

One trip or a course?

One session gives a noticeable boost. The full effect needs 3–4 sessions about 3 weeks apart, so plan it as a yearly Seoul top-up, or finish the course at home where it's available.

+

Combining treatments

Seoul clinics often pair it with a lifting treatment like Shurink or Ultherapy in the same visit. Ask the doctor what order they use.

For the next 1–2 days, skip:Alcohol for a day or twoSaunas and jjimjilbang for a couple of daysIntense workouts the same dayUnprotected sun: wear SPF 50
Best season for Rejuran in Seoul

Rejuran works in any month, but its tiny injection wounds and 24–48 hour no-heat rule are easiest to respect from October to March, when Seoul's UV index sits at 2–5 and there's no monsoon humidity.

  • SpringFine, but March to May is peak fine-dust and yellow-dust season, and fine dust weakens the skin barrier. UV climbs to 7–8 by April and May, so pack SPF 50.
  • SummerThe hardest season: UV peaks around 9–10 and July humidity averages 76% in the jangma rains. Surgeons advise avoiding heat and heavy sweating for 24–48 hours after injections.
  • AutumnBest from October, when UV drops to 3–4 and the humidity goes. Early September is still warm with UV around 7.
  • WinterLowest UV of the year (about 2) and little sweating. The air is at its driest, so bring a rich moisturiser and skip the jjimjilbang for two days.
What age is Rejuran best for?
  • 20sA 2026 Rejuran trial averaged age 31 and improved fine lines and pores. Korean dermatologists also use PN widely for acne scars; with no scars or texture issues you may not need it yet.
  • 30sWell supported: in a small Korean series, women in their 30s saw the clearest gains in pores and skin thickness.
  • 40sIn the same series, women in their 40s improved most in tone, wrinkles and sagging. A crow's-feet study averaged about 44.
  • 50+A small PN trial averaging age 50 showed better pores and wrinkles only on the side treated with a needle-free jet injector, not with standard needles. Collagen production falls with age and PN doesn't lift, so pair it with a lifting treatment.
At the clinic

Rejuran at the clinic: red flags and what to say

Walk out if…

  • A price far below this week's Seoul median. Ask exactly which product and how many cc you're getting
  • The clinic can't or won't show you the sealed product before it's opened (ask for 정품 확인)
  • Generic “PN” products sold as Rejuran. They may be fine, but they're a different product at a different price
  • No doctor consultation before injecting
  • Pressure to buy a multi-session package on the spot

Say it in Korean

리쥬란 힐러 2cc 얼마예요?
Rijuran hilleo i-ssi-ssi eolmayeyo?
How much is Rejuran Healer, 2cc?
이벤트 가격 있어요?
Ibenteu gagyeok isseoyo?
Is there an event (promotion) price?
정품 확인할 수 있을까요?
Jeongpum hwagin hal su isseulkkayo?
Can I check it's the genuine product?
리쥬란 HB 플러스로 할 수 있어요?
Rijuran HB peulleoseu-ro hal su isseoyo?
Can I have Rejuran HB Plus instead?
마취 크림 발라 주세요.
Machwi keurim balla juseyo.
Please apply numbing cream.
FAQ

Rejuran: questions people actually ask

Is Rejuran really made from salmon?

Yes. Its active ingredient, polynucleotides, is purified from salmon DNA. Tell the doctor if you have a fish allergy.

Is one session worth it on a short trip?

For many people, yes: skin often looks more rested and hydrated within days. The full effect on fine lines and pores comes from a course of 3–4 sessions about 3 weeks apart.

How many days before my flight should I get Rejuran?

At least 2 full days, so the bumps are gone. Leave about a week if you have an important event, because a bruise can take 1–2 weeks to fade.

Can I get Rejuran in the US?

Rejuran is not FDA-approved in the United States; a few clinics offer it off-label. In Singapore it typically costs S$600–1,000 per session and in Australia A$900–1,200 per Healer syringe.

What's the difference between Rejuran Healer and HB Plus?

HB Plus adds hyaluronic acid and lidocaine, a local anaesthetic, so it's noticeably less painful. It usually costs a little more.

Does Rejuran hurt?

It's one of the more uncomfortable skin boosters because of the number of injections. Numbing cream helps; HB Plus or a nerve block helps more.

More detail

The fine print on Rejuran

What is Rejuran? The hard facts
Active ingredient
Polynucleotides (PN), purified from salmon DNA
Made by
PharmaResearch, South Korea
Versions
Healer (original) · HB Plus (adds hyaluronic acid + lidocaine) · i (under-eye) · S (scars)
How it's given
Many tiny injections across the face (or by injector device)
Numbing
Topical cream; nerve block optional at some clinics
Treatment time
About 30–40 minutes, plus numbing
Visible bumps
Like mosquito bites; almost unnoticeable after 24 hours
Makeup
From about 24 hours after
Bruising (if any)
Can last 1–2 weeks
Full course
3–4 sessions, about 3 weeks apart
Maintenance
Once every 6–12 months
Standard dose
2cc per full-face session (the size we price)
Rejuran vs. Juvelook vs. hyaluronic skin boosters
RejuranJuvelookHA booster (물광)
What it isPolynucleotides (salmon DNA)PDLLA + hyaluronic acidHyaluronic acid
Main jobRepair, skin quality, glowCollagen stimulation, volume-ish textureHydration, instant glass-skin glow
How fast you see itDays, builds over a courseWeeks to a few monthsWithin days
Visible downtime~1–3 daysA few days~1–2 days
Best for a short trip?YesBetter with time to settleYes
Seoul price this week₩209,000₩197,900—
How does Rejuran work? The science

Polynucleotides are chains of DNA fragments. Injected into the skin, they are thought to support the cells that make collagen (fibroblasts) and to help the skin repair itself.

A 2025 systematic review in the Journal of Cosmetic Dermatology found nine studies with 219 patients in total. Results for wrinkles, texture and elasticity were positive, side effects were mild and short-lived, but the studies were of low to moderate quality.

Newer split-face trials compare injection techniques and depths, and a 2026 study reported improvement in under-eye wrinkles after the first and especially the second session.

In short: a plausible mechanism and encouraging early results, but not yet the large trials behind treatments like Botox.

Sources (19)
  1. Smart Skin Clinic: Rejuran timeline, sessions and aftercare
  2. Medical Travel Korea: Rejuran Healer beginner's guide (versions, manufacturer)
  3. Dr. Kim: FDA status of PN/PDRN injections in the US
  4. Lampridou et al., The Effectiveness of Polynucleotides in Esthetic Medicine: A Systematic Review (2025)
  5. Ziade et al., Polynucleotide Injections for Periorbital Rhytides (2026)
  6. Terris: Rejuran prices in Singapore (2026)
  7. Cosmetic Connection: Rejuran cost in Australia
  8. Weather2Travel: Seoul monthly max UV index (2 in Dec–Jan, 7–8 in Apr–May, 10 in July, 4 in Oct)
  9. Climate of Seoul (KMA 1991–2020 normals: humidity lowest Feb–Mar at 54.6%, highest July at 76.2%, July rainfall 414 mm)
  10. Korea Times: yellow dust and fine dust typically peak March to May (2025)
  11. Kim et al., Particulate matter causes skin barrier dysfunction, JCI Insight (2021): Seoul PM2.5 raised water loss
  12. American Society of Plastic Surgeons: what not to do after facial filler (avoid heat 24–48 h, exercise 24 h)
  13. Park et al., Effects of winter indoor environment on the skin in Korea, Skin Res Technol (2023)
  14. Bae et al., Intradermal vs subdermal Rejuran, prospective split-face study, J Cosmet Dermatol (2026): mean age 31
  15. Park et al., Long-chain polynucleotide filler for skin rejuvenation in five patients, Dermatol Ther (2016): 30s vs 40s findings
  16. Hong et al., Needle vs needle-free injection of PN filler, J Cosmet Dermatol (2025): mean age 49.9
  17. Rho et al., PN injections for scar prevention and management: KAAD survey of 501 dermatologists (2026)
  18. Varani et al., Decreased collagen production in chronologically aged skin, Am J Pathol (2006)
  19. Lee et al., PN vs hyaluronic acid filler for periocular rejuvenation: randomised, double-blind, split-face trial of 27 people, J Dermatolog Treat (2022)

More research on Rejuran Healer

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General information for travellers, not medical advice. A doctor should assess you before any treatment. Prices are Korean-consumer event prices collected from public listings; clinics may charge differently on the day.